Manager Toshack is without 14 of his best players for the friendly, with skipper Simon Davies due to win his 50th cap.
Hull goalkeeper Boaz Myhill and Stockport defender Ashley Williams are expected to make their debuts, and Toshack said: “The most important thing is that we don’t treat this game lightly. We mustn’t end up blaming the fact that we are without so many players.
“It is not important who you are playing against, it is important who you are playing for.
“You are playing for your country, be it against Luxembourg or Germany. We are playing for Wales and everyone must realise we are here for a reason.
“Our attitude will be what is expected. We need to put in a good shift for this one.
“It will be a tough game – Luxembourg have beaten Belarus recently so we know what they are capable of.”
Toshack praised Davies’ contribution to his country.
He said: “Simon has been very good for us. He has led by example and I am pleased with him, and he can be delighted with 50 caps.
“He has had a rough time at Fulham this season as they fight to avoid relegation, but he is committed to Wales and should be very proud of his achievement.
“Simon is a model pro and a great example. He’s our most experienced player now, a super example for others.
“He was a bit down a year or so ago, he had a shin problem he couldn’t get rid of and he wasn’t playing as often as he would have liked at Everton.
“He got his move back to London and he is more settled now. He is a very, very good player and he is well rated in the game.”